PROTEASE INHIBITOR (SIDE) EFFECTS
Invirase &AEling; (Hoffmann-LaRoche)
Body as a whole: allergic reaction, chest pain, edema, fever, intoxication,
parasites external, retrosternal pain, shivering, wasting syndrome, weight
decrease.
Cardiovascular: Cyanosis, heart murmur, heart valve disorder, hypertension,
hypotension, syncope, vein distended.
Endocrine/Metabolic: Dehydration, dry eye syndrome, hyperglycemia, weight
increase, xerophthalmia.
Gastrointestinal: Cheilitis, constipation, dysphagia, eructation, feces
bloodstained, feces discolorred, gastralgia, gastritis, gastrointestinal
inflammation, gingivitis, glossitis, hemorrhage rectum, hemorrhoids, hepatomegaly,
melena, pain pelvic, painful defecation, pancreatitis, parotic disorder,
salivary glands disorder, stomatitis, tooth disorder, vomiting.
Hematlogic: Anemia, microhemorrhages, pancytopenia, splenomegaly, thrombocytopenia.
Musculoskeletal: Arthralgia, arthritis, back pain, cramps muscle, musculoskeletal
disorders, stiffness, tissue changes, trauma.
Neurological: Ataxia, bowel movements frequent, confusion, convulsions,
dysarthria, dysesthesia, heart rate disorder, hyperesthesia, hyperreflexia,
hyporeflexia, mouth dry, numbness face, pain facial, paresis, poliomyelitis,
progressive multifocal leukoencephalopathy, spasms, tremor.
Psychological: Agitation, amnesia, anxiety, depression, dream excessive,
euphoria, hallucination, insomnia, intellectual ability reduced, irritability,
lethargy, libido disorder, overdose effect, psychotic disorder, somnolence,
speech disorder.
Reproductive System: Prostate enlarged, vaginal discharge.
Resistance Mechanism: Abscess, angina tonsillaris, candidiasis, hepatitis,
herpes simplex, herpes zoster, infection bacterial, infection mycotic, infection
staphylococcal, influenza, lymphadenopathy, tumor.
Respiratory: Bronchitis, cough, dyspnea, epistaxis, hemoptysis, laryngitis,
pharyngitis, pneumonia, respiratory disorder, rhinitis, sinusitis, upper
respiratory tract infection.
Skin and Appendages: Acne, dermatitis, dermatitis seborrheic, eczema,
erythema, folliculitis, furunculosis, hair changes, hot flushes, photosensitivity
reaction, pigment changes skin, rash maculopapular, skin disorder, skin
nodule, skin ulceration, sweating increased, urticaria, verruca, xeroderma.
Special Senses: Blepharitis, earache, ear pressure, eye irritation, hearing
decreased, otitis, taste alteration, tinnitus, visual disturbance.
Urinary system: Micturition disorder, urinary tract infection.
Crixivan &AEling; (Merck, Sharp & Dohme)
Body As A Whole/Site Unspecified: Abdominal distention, chest pain, chills,
fever, flank pain, flu-like illness, fungal infeciton, malaise, pain, syncope.
Cardiovascular System: Cardiovascular disorder, palpitation.
Digestive System: Acid regurgitation, anorexia, aphthous stomatitis,
cheilitis, cholecystitis, cholestasis, constipation, dry mouth, dyspepsia,
eructation, flatulence, gastritis, gingivitis, glossodynia, gingival hemorrhage,
increased appetitie, infectious gastroenteritis, jaundice, liver cirrhosis.
Hemic and Lymphatic System: Anemia, lymphadenopathy, spleen disorder.
Metabolic/Nutritional/Immune: Food allergy.
Musculoskeletal System: Arthralgia, back pain, leg pain, myalgia, muscle
cramps, muscle weakness, musculoskeletal pain, shoulder pain, stiffness.
Nervous system and Psychiatric: Agitation, anxiety, anxiety disorder,
bruxism, decreased mental acuity, depression, dizziness, dream abnormality,
dysesthesia, excitement, fasciculation, hypesthesia, nervousness, neuralgia,
neurotic disorder, paresthesia, peripheral neuropathy, sleep disorder, somnolence,
tremor, vertigo.
Respiratory System: Cough, dyspnea, halitosis, pharyngeal hyperemia,
pharyngitis, pneumonia, rales/rhonchi, respiratory failure, sinus disorder,
sinusitis, upper respiratory infection.
Skin and Skin Appendage: Body odor, contact dermatitis, dermatitis, dry
skin, flushing, folliculitis, herpes simplex, herpes zoster, night sweats,
pruritus, seborrhea, skin disorder, skin infection, sweating, urticaria.
Special Senses: Accommodation disorder, blurred vision, eye pain, eye
swelling, orbital edema, taste disorder.
Urogenital System: Dysuria, hematuria, hydronephrosis, nocturia, premenstrual
syndrome, proteinuria, renal colic, urinary frequency, urinary tract infection,
urine abnormality, urine sediment abnormality, urolithiasis.
Sources: Merck and Hoffmann-La Roche package inserts for Crixivan &AEling; and
Invirase &AEling;.
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